Effects of an Antibiotic From Aspergillus fumigatus Fresenius on Tumor Cells in Vitro , and Its Possible Identity With Gliotoxin

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Abstract
A mold, isolated originally from the air of an animal room and later identified as A. fumigatus, provides culture filtrates that will regularly render the cells of various animal tumors incapable of further proliferation upon brief contact with them in vitro. Recently a crystalline subst. identical with, or similar to, gliotoxin has been isolated from the culture filtrates. Both this material and purified gliotoxin procured from another source have likewise proved highly active against tumor cells in vitro. Exptl. results indicate that the active material produced by A. fumigatus is probably identical with gliotoxin.