Measurement of left ventricular ejection fraction with ionic 113mIn and a cardiac probe

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Abstract
Left ventricular ejection fraction (LVEF) was measured with a cardiac probe (Nuclear Stethoscope, Bios Inc., Valhalla, New York) and 113mIn in 28 normal subjects and 86 patients with coronary artery disease (CAD). In 20 normal subjects 99mTC-RBCs were compared with 113mIn which binds to transferrin after IV injection. With 99mTc-RBCs, average LVEF was 57±7% (1 SD); with 113mIn, average LVEF was 55±8% (N.S.). Sequential measurements at different times over 60 min revealed good reproducibility. Comparison of LVEFs obtained using 99mTc-RBCs with a gamma camera and cardiac probe revealed a good correlation. The correlation coefficients were 0.92 in 25 patients with CAD and 0.95 in 10 patients with LV wall motion abnormalities. The LVEF obtained using a cardiac probe and 113mIn increased in 28 normals from 57±9% to 64±13% (PPPP113mIn provide a useful alternate means of determining left ventricular dysfunction in facilities where 99mTc and a gamma camera computer system are not readily available.