CAMPYLOBACTER-JEJUNI COLITIS IN GNOTOBIOTIC DOGS

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  • 1 January 1981
    • journal article
    • research article
    • Vol. 45  (4) , 377-383
Abstract
C. jejuni of human and canine origin was inoculated orally into 6 gnotobiotically reared Beagle puppies and reactions were compared with 2 controls. Inoculated dogs developed transient lassitude, inappetence, mild diarrhea and tenesmus during the period 36-72 h after inoculation. Pairs of dogs killed 43 h, and 5 and 7 days after inoculation had lesions limited to typhlitis and colitis. Congestion of colonic mucosa, associated loss of goblet cells, attenuation and exfoliation of surface epithelium with microerosions, hypertrophy of glands and neutrophil infiltration of lamina propria were seen during the acute phase. Less severe surface and inflammatory lesions were evident at 5 and 7 days, with hyperplasia of the proliferative compartment in mucosal glands. Campylobacter established at over 1010 organisms/g of colonic content but did not invade the mucosa. Thus, the gnotobiotic dog may be a suitable model for investigation of the pathogenesis of Campylobacter colitis.

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