NFκB in neurons? The Uncertainty Principle in neurobiology
Open Access
- 29 March 2006
- journal article
- review article
- Published by Wiley in Journal of Neurochemistry
- Vol. 97 (3) , 607-618
- https://doi.org/10.1111/j.1471-4159.2006.03810.x
Abstract
Nuclear factor κB (NFκB) is a dynamically modulated transcription factor with an extensive literature pertaining to widespread actions across species, cell types and developmental stages. Analysis of NFκB in a complex environment such as neural tissue suffers from a difficulty in simultaneously establishing both activity and location. Much of the available data indicate a profound recalcitrance of NFκB activation in neurons, as compared with most other cell types. Few studies to date have sought to distinguish between the various combinatorial dimers of NFκB family members. Recent research has illuminated the importance of these problems, as well as opportunities to move past them to the nuances manifest through variable activation pathways, subunit complexity and target sequence preferences.Keywords
This publication has 116 references indexed in Scilit:
- PERK is responsible for the increased phosphorylation of eIF2α and the severe inhibition of protein synthesis after transient global brain ischemiaJournal of Neurochemistry, 2005
- NF-κB factor c-Rel mediates neuroprotection elicited by mGlu5 receptor agonists against amyloid β-peptide toxicityCell Death & Differentiation, 2005
- Dimerization Is Required for Activation of eIF2 Kinase Gcn2 in Response to Diverse Environmental Stress ConditionsJournal of Biological Chemistry, 2004
- Nuclear Factor-κB Modulates the p53 Response in Neurons Exposed to DNA DamageJournal of Neuroscience, 2004
- To be, or not to be: NF-κB is the answer – role of Rel/NF-κB in the regulation of apoptosisOncogene, 2003
- Neuronal κB-binding Factors Consist of Sp1-related ProteinsPublished by Elsevier ,2002
- NF‐κB is involved in the survival of cerebellar granule neurons: association of Iκβ phosphorylation with cell survivalJournal of Neurochemistry, 2001
- Viral Persistence in Neurons Explained by Lack of Major Histocompatibility Class I ExpressionScience, 1991
- The DNA binding subunit of NF-κB is identical to factor KBF1 and homologous to the rel oncogene productCell, 1990
- Sites of antigen presentation in T-cell mediated demyelinating diseasesResearch in Immunology, 1989