HEMODYNAMICS, CORONARY BLOOD-FLOW AND MYOCARDIAL-METABOLISM IN MAN - EFFECTS OF SUFENTANIL AND FENTANYL

  • 1 January 1980
    • journal article
    • research article
    • Vol. 29  (5) , 277-279
Abstract
The effects of sufentanil (0.7 .mu.g/kg) and fentanyl (7 .mu.g/kg) on general and coronary hemodynamics and myocardial metabolism were studied in 6 and 9 patients without cardiovascular disease. Both drugs produced a slight reduction in heart rate, cardiac index and mean aortic pressure while peripheral vascular resistance remained unchanged. There was a decrease in dp/dtmax [maximum rate of pressure change] and a slight increase in LVEDP [left ventricular end diastolic pressure] suggesting minimal depression of myocardial contractility. Myocardial blood flow and myocardial O2 uptake slightly decreased due to reduction in pressure-, volume- and frequency-load and dp/dtmax. With both drugs, arterial concentrations of glucose, lactate, pyruvate and free fatty acids and their myocardial uptake did not change significantly. Clinically equi-anesthetic doses of sufentanil and fentanyl produced almost identical effects on general and coronary hemodynamics. With regard to the cardiovascular actions, sufentanil offers no advantage over fentanyl.

This publication has 0 references indexed in Scilit: