Forskolin supresses seizures induced by pentylenetrazol in mice
- 1 November 1984
- journal article
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 40 (11) , 1270-1271
- https://doi.org/10.1007/bf01946669
Abstract
Forskolin, an adenylate cyclase activator when injected s.c. (1 mg/kg) in mice, caused an elevation of cAMP in the forebrain and cerebellum of up to 170% and 130%, respectively. The treatment was found to prevent seizures induced by pentylenetetrazol. This suppression had subsided 30 min after the injection, when cAMP level was again normal in the cerebellum but still elevated in the forebrain.Keywords
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