1,25-Dihydroxycholecalciferol: A Potent Stimulator of Bone Resorption in Tissue Culture
- 18 February 1972
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 175 (4023) , 768-769
- https://doi.org/10.1126/science.175.4023.768
Abstract
1,25-Dihydroxycholecalciferol (DHCC), isolated from kidney homogenates incubated with 25-hydroxycholecalciferol (HCC), stimulated the release of previously incorporated 4545Ca from fetal rat bones in organ culture, at concentrations of 10-10 to 10-8M. The dose response curves for 1,25-DHCC and 25-HCC, the parent compound, are parallel, but 1,25-DHCC is about 100 times as potent on a weight basis. Brief exposure to maximum doses of either agent leads to prolonged bone resorption.Keywords
This publication has 13 references indexed in Scilit:
- Induction of Bone Resorption in Tissue Culture: Prolonged Response after Brief Exposure to Parathyroid Hormone or 25-HydroxycholecalciferolEndocrinology, 1972
- Bone mineral mobilization activity of 1,25-dihydroxycholecalciferol, a metabolite of vitamin DArchives of Biochemistry and Biophysics, 1971
- Biological activity 1,25-dihydroxycholecalciferolBiochemistry, 1971
- Isolation and identification of 1,25-dihydroxycholecalciferol. A metabolite of vitamin D active in intestineBiochemistry, 1971
- Vitamin D Metabolism: The Role of Kidney TissueScience, 1971
- Unique Biosynthesis by Kidney of a Biologically Active Vitamin D MetaboliteNature, 1970
- Metabolism and subcellular location of 25-hydroxycholecalciferol in intestinal mucosaBiochemistry, 1970
- 25-Hydroxycholecalciferol: Direct Effect on Calcium TransportScience, 1969
- 25-Hydroxycholecalciferol: Stimulation of Bone Resorption in Tissue CultureScience, 1969
- The synthesis of 25-hydroxycholecalciferol. A biologically active metabolite of vitamin D3Biochemistry, 1969