MORPHOLOGIC CHANGES IN RED BLOOD CELL WITH IRON DEFICIENCY ANEMIA

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Abstract
One of the most signal forward steps in the field of hematology is a recognition of the fact that the term "secondary anemia" must give way to a descriptive diagnosis which implies the etiologic component. Next to infection, iron deficiency is probably the most common cause of anemia. It is our purpose to point out certain characteristics of the blood as determined from the analysis of 628 cases of iron deficiency, in each of which bleeding, either alone or in combination with other factors, was responsible for the anemia. We have become particularly impressed with the progressive changes which take place in the red cells as the iron deficient state becomes more and more definite, and the correlation of these changes with the severity of iron deficiency and the degree of anemia. Another point of practical importance which became apparent as the study progressed was the independent rate of fall

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