Bovine collagen. I. Changes in collagen solubility with animal age

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Abstract
Summary. The changes with animal age in the concentrations of five forms of collagen of differing solubility characteristics were followed in bovine l. dorsi, skin and tendon. Those forms which were extractable in neutral salt and dilute acid were found to increase swiftly during the gestation period and fall to low levels between birth and 1–2 years of age in the three tissues. After birth there was a rapid rise in the concentrations of the more insoluble forms of collagen and these greatly predominated by 1–2 years of age in each tissue. The relative time relations of the changes were compatible with a transformation of the easily extractable forms into the more insoluble ones with increasing age.In muscular tissue only, after about 2 years of age, there was some diminution in total collagen and also in the proportion of the latter which resisted extraction. Possible reasons were discussed.