M ller glial cells in anuran retina

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Abstract
Whereas in the brain, the activity of the neurons is supported by several types of glial cells such as astrocytes, oligodendrocytes, and ependymal cells, the retina (evolving from the brain during ontogenesis) contains only one type of macroglial cell, the Müller (radial glial) cells, in most vertebrates including the anurans. These cells span the entire thickness of the tissue, and thereby contact and ensheath virtually every type of neuronal cell body and process. This intimate topographical relationship is reflected by a multitude of functional interactions between retinal neurons and Müller glial cells. Müller cells are the principal stores of retinal glycogen, and are thought to fuel retinal neurons with substrate (lactate/pyruvate) for their oxidative metabolism. Furthermore, Müller cells are involved in the control and homeostasis of many constituents of the extracellular space, such as potassium and perhaps other ions, signaling molecules, and of the extracellular pH. They also seem to play important roles in recycling mechanisms of photopigment molecules and neurotransmitter molecules such as glutamate and GABA. By containing the main retinal stores of glutathione, Müller cells may protect retinal neurons against free radicals. Moreover, Müller cells express receptors for many neuroactive substances, and may also release such substances to their neighbouring neurons. Thus, Müller cells exert many functions crucial for signal processing in the normal retina. Moreover, Müller cells change their properties in cases of retinal disease and injury, and may either support the survival of neuronal cells or accelerate the progress of neuronal degeneration.