Curvularia lunata Endocarditis Treated with Terbinafine: Case Report

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Abstract
A 44-year-old man developedendocarditis due to Curvularia lunataon a Carpentier-Edwards porcine heterograft with clinical involvement of the ring of the aortic valve and the aortic root. Becausecurative surgery wasconsidered to be extremely high risk, he wastreated with antifungal drugs for nearly 7 years. Initial treatment with amphotericin Band ketoconazole wasfollowedby long-term treatment with terbinafine, an experimental allyamine derivative. No adverse effects were attributed to terbinafine. At surgery nearly 7 years later, the aortic valvering and aortic root appeared to be uninvolved,and the valvewas replaced uneventfully.To our knowledge,this is the first report of successful treatment of curvularia endocarditis.

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