Arterial pressure pulse contours during hemorrhage in anesthetized dogs

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Abstract
Experiments performed on anesthetized dogs demonstrated the relationship between stroke volume and several different arterial pressure pulse contour values over wide ranges of heart rate and cardiac output. The most reliable index of stroke volume was found to be the difference between mean and diastolic blood pressures recorded from the ascending aorta. Continuous computation of the product of this pressure difference and heart rate provides a continuous estimation of cardiac output that is sufficiently reliable for use in the teaching of cardiovascular physiology to first-year medical students.

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