Influence of Age and Sex on Carcinoma and Cirrhosis of the Liver in AXC Strain Rats Ingesting 0.025% N-2-Fluorenyldiacetamide

1 January 1975

journal article
research article
Published by S. Karger AG in Pathobiology

Vol. 43 (1) , 31-37
https://doi.org/10.1159/000162792

Abstract

Inbred A×C male and female rats, 4, 12, 24, and 52 weeks of age, ingested 0.025% N-2-fluorenyldiacetamide in a semisynthetic diet. Both age and sex were important in the development of hepatic lesions. The 4- and 12-week-old males developed a higher incidence of carcinomas and cirrhosis of the liver than did the females of the same ages or the males and females 24 and 52 weeks of age. Four-week-old male rats had more carcinomas per liver, larger carcinomas, more poorly differentiated (as compared with well differentiated), and some carcinomas were cholangiocellular as well as hepatocellular. There were a few hepatic lesions in the younger female rats; however, female rats of all ages were relatively resistant to hepatic carcinogenesis.

Keywords

This publication has 1 reference indexed in Scilit:

Development of Preneoplastic and Neoplastic Lesions of the Liver in Male Rats Given 0.025 Percent N-2-Fluorenyldiacetamide2
JNCI Journal of the National Cancer Institute, 1965