H-2-Controlled polymorphism of the γ chain of Slp (sex-limited protein)

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Abstract
A genetic polymorphism detected by the O'Farrell two-dimensional technique (isoelectric focusing and SDS-PAGE) of the murine sex-limited protein (Slp) is described and shown to map to theH-2 complex. The Slp charge variation was found to be in theγ chains. Inbred strains carrying theH-2 w7 andH-2 wr7 haplotypes, which are derived from a wild mouse, had Slp-γ chains with pI = 6.55 (Slp-lb). All other inbred strains, bearingH-2ij,H-2 s ,H-2 p ,H-2 d ,H-2 u , as well as three additional Slp-constituive wild females captured in Chile, had Slp-γ chain with pI = 6.71 (Slp-la).