Irreversible and reversible blockade of IMR32 calcium channel currents by synthetic MVIIA and iodinated MVIIC ?-conopeptides
- 1 April 1995
- journal article
- Published by Springer Nature in Pflügers Archiv - European Journal of Physiology
- Vol. 429 (6) , 873-875
- https://doi.org/10.1007/bf00374813
Abstract
The actions of two ω-conopeptides on high-voltage-activated calcium channel currents in differentiated human neuroblastoma IMR32 cells were investigated. Similar to the previously reported action of ω-conopeptide GVIA, ω-conopeptide MVIIA irreversibly blocks IMR32 HVA calcium channel currents at low concentrations. Unlike GVIA action, however, novel w-conopeptide SNX-260 (iodinated MVIIC) reversibly blocks these currents, also at low concentrations, with an IC50 near 50 nM. Different ω-conopeptides may be potent blockers of HVA calcium channel currents yet act either reversibly or irreversibly in a single cell.Keywords
This publication has 9 references indexed in Scilit:
- Roles of N-Type and Q-Type Ca 2+ Channels in Supporting Hippocampal Synaptic TransmissionScience, 1994
- Distinctive biophysical and pharmacological properties of class A (BI) calcium channel α1 subunitsNeuron, 1993
- A new conus peptide ligand for mammalian presynaptic Ca2+ channelsNeuron, 1992
- P-type calcium channels blocked by the spider toxin ω-Aga-IVANature, 1992
- Ca currents in human neuroblastoma IMR32 cells: kinetics, permeability and pharmacologyPflügers Archiv - European Journal of Physiology, 1990
- Multiple types of neuronal calcium channels and their selective modulationTrends in Neurosciences, 1988
- Neuronal calcium channel antagonists. Discrimination between calcium channel subtypes using .omega.-conotoxin from Conus magus venomBiochemistry, 1987
- Definition of a continuous human cell line derived from neuroblastoma.1970