Development of the Endocrine Pancreas of Rats as Manifested by the Appearance of Argyrophilia and Granulation

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Abstract
Previous studies have shown that the pancreatic islet tissue contains two separate types of A cells depending on the presence (=Al cells) or absence (=A2 cells) of an argyrophil cytoplasmic reaction. The occurrence of argyrophil A1 cells and their degree of blackening was studied in the early postnatal life of rats from normal or alloxan diabetic mothers. Blackened A1 cells were present at birth, the most pronounced argyrophilia seen in rats from diabetic mothers. The islets in the latter had a stronger argyrophil reaction even at 5 days of age. The granule content of the islet cells, as observed in dark field illumination, was studied in foetuses and suckling rats from normal mothers. Sparse refractive granules were visible at the 18th gestational day and well granulated islets at birth. The islet B cells of 10 days old animals had about the same granule content as adult rats.

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