An Age‐Associated Decrease in the Frequency of C4B*Q0 Indicates That Null Alleles of Complement May Affect Health or Survival
- 1 December 2003
- journal article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 1010 (1) , 496-499
- https://doi.org/10.1196/annals.1299.091
Abstract
To access publisher full text version of this article. Please click on the hyperlink in Additional Links fieldWe studied the distribution of complement C4, C3, and factor B allotypes in 423 healthy Icelandic subjects from 17 to 89 years of age. A marked decrease was observed in the carrier frequency of variant alleles of complement C4B (C4B(*)Q0) and C3 (C3(*)F). These results confirm our previous observations on Hungarian subjects and suggest a negative effect of C4B(*)Q0 on health or survivalKeywords
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