Microscopic adenoma in nonpolyposis coli

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Abstract
Six microscopic adenomas found in 4 patients of nonpolyposis coli (namely, not included in the group of familial polyposis coli) which were detectable microscopically but not macroscopically, were examined by preparing complete serial section. With respect to the histogenesis of large intestinal adenomas in nonpolyposis coli, they are considered to originate from the basal cells. As the background for this, a great number of adenomatous changes in basal cells were seen and the microscopic adenomas showed a tendency of multiplicity (in the present study a total of 36 microscopic adenomas were detected). The above-described adenomatous changes in basal cells and development of microscopic adenomas are apparently, closely related to lymphoid follicles on the muscularis mucosa, with 20 (55.6%) of 36 microscopic adenomas originating in the basal cell upon the lymphoid follicles.