Colloid Chemical Studies on the Aggregation of Phospholipid Vesicles with Metal Cations

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Abstract
Aggregation behavior of phosphatidylethanolamine (PE) and Phosphatidylserine (PS) vesicles that have resulted with various metal cations, has been studied to determine their adsorption characteristics. The critical flocculation concentration of these cations for both vesicles was determined by two techniques, i.e., by the kinetic method in which the rate of flocculation was measured turbidimetrically, and by the traditional static method. The results have been analysed by the usual stability concept in the colloid chemistry, and these analyses revealed that there are two mechanisms in the vesicle aggregation. One is the charge neutralization of the polar groups on the vesicle surface, which is induced by the adsorption of multivalent cations (Th4+, La3+), and the other is the interparticle binding (or the interparticle bridging) caused by the divalent cations (Ca2+, Mg2+).