Histocompatibility studies in pre-eclampsia
- 11 December 2008
- journal article
- research article
- Published by Wiley in Tissue Antigens
- Vol. 29 (5) , 232-236
- https://doi.org/10.1111/j.1399-0039.1987.tb01582.x
Abstract
Full HLA-A, B and DR types were obtained for 22 families (mothers, fathers and neonates) associated with severe (proteinuric) pre-eclampsia, 21 families associated with mild pre-eclampsia, and 132 families associated with normal pregnancies. There was an increased frequency of DR4 (relative risk 3.6: p < 0.003, uncorrected) in both neonates and mothers of the severe pre-eclampsia families when compared to the normotensive controls. There were no significant differences between either pre-eclampsia group and controls in HLA antigen homozygosity. HLA antigen sharing or in lymphocytotoxin production.This publication has 16 references indexed in Scilit:
- Haplotype frequencies in South‐East ScotlandTissue Antigens, 1987
- Genetics of hypertension in pregnancy: possible single gene control of pre‐eclampsia and eclampsia in the descendants of eclamptic womenBJOG: An International Journal of Obstetrics and Gynaecology, 1986
- Enzymatic modification of the lymphocyte surfaceTissue Antigens, 1983
- Hypertension in PregnancyMedicine, 1981
- Pre-eclampsia and changed paternityEuropean Journal of Obstetrics & Gynecology and Reproductive Biology, 1980
- Eclampsia in multipara.BMJ, 1980
- Genetic control of severe pre-eclampsia.Journal of Medical Genetics, 1979
- Antigens of human trophoblasts: A working hypothesis for their role in normal and abnormal pregnanciesProceedings of the National Academy of Sciences, 1978
- Human leucocyte antigens and mixed lymphocyte reaction in severe pre-eclampsia.BMJ, 1978
- Pathological Anatomy of Acute Hypertension of PregnancyCirculation, 1964