Bovine spongiform encephalopathy agent in spleen from an ARR/ARR orally exposed sheep
Open Access
- 1 April 2006
- journal article
- Published by Microbiology Society in Journal of General Virology
- Vol. 87 (4) , 1043-1046
- https://doi.org/10.1099/vir.0.81318-0
Abstract
Oral contamination with bovine spongiform encephalopathy (BSE) agent in susceptible PRNP genotype sheep results in widespread distribution of prion in the host. Because ARR homozygous sheep are considered to be resistant to transmissible spongiform encephalopathies, they have been selected to eradicate scrapie from sheep flocks and to protect the human food chain from small ruminant BSE risk. However, results presented here show that several months after an oral challenge with BSE agent, healthy ARR/ARR sheep can accumulate significant amounts of PrPScin the spleen.This publication has 14 references indexed in Scilit:
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