THE RADIATION-DOSIMETRY OF 2-[F-18]FLUORO-2-DEOXY-D-GLUCOSE IN MAN

  • 1 January 1982
    • journal article
    • research article
    • Vol. 23  (7) , 613-617
Abstract
Bladder and brain time-activity measurements in humans were performed after i.v. administration of 2-[18F]fluoro-2-deoxy-D-glucose [a drug used to measure metabolism of glucose]. Radiation doses were calculated using the MIRD [medical internal radiation dose] schema. The bladder wall received an average of 440 mrad/mCi (SE 76) in 10 subjects who voided at 2 h after administration of tracer. If these subjects had voided at 1 h, the bladder-wall dose would have been reduced to 220 mrad/mCi. The brain received an average of 81 mrad/mCi in 8 subjects. The doses to other organs, calculated from published dog biodistribution data, are between 50 and 85 mrad/mCi except for spleen and heart, which both received 160 mrad/mCi. These time-activity measurements for the critical organ in the human avoid the assumptions made in using animal biodistribution data for human dosimetry calculations.

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