Effects of ACTH 4–10 on ECT‐induced memory dysfunctions

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Abstract
Double-blind studies of ACTH 4-10 and placebo were conducted in psychiatric patients receiving bilateral ECT [electroconvulsive therapy] to determine whether the polypeptide exerted anti-amnesic effects. Observations after a single ECT showed some positive effects, but studies between seizures after 5 or 6 ECT showed no significant drug-placebo differences. Although the findings were largely negative, they did not rule out positive effects of ACTH 4-10 on memory. Possibly the designs and timing of the experiments and/or the dosages of ACTH 4-10 employed were unsuitable for demonstrating such influences.