Survival of MM red cells during hypothermia in two patients with anti-M

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Abstract
The in vivo survival of M(M+N-) red cells in 2 patients with anti-M was studied during hypothermia. The antibodies were IgM, of low titer and did not react at 30.degree.C. 51Cr survival studies were performed using 2 ml of labeled blood. There was normal circulation of M(M+N-) cells at 37.degree. C and no accelerated loss of these cells at blood temperatures between 16.degree. and 28.degree. C. One patient received 187 ml of MN(M+N+) red cells when the blood temperature was 25.degree. C without evidence of clinical transfusion reactions or development of positive direct anti-human globulin test. Hypothermia did not adversely affect the immediate survival of M(M+N-) red cells transfused to patients with anti-M antibodies reactive in vitro below 30.degree. C.

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