Hemeoxygenase-1 in SJL mice with experimental allergic encephalomyelitis
- 1 August 2003
- journal article
- research article
- Published by SAGE Publications in Multiple Sclerosis Journal
- Vol. 9 (4) , 372-381
- https://doi.org/10.1191/1352458503ms928oa
Abstract
The expression of heme oxygenase-1 (HO -1) is increased in the C NS of mice and rats with experimental allergic encephalo myelitis (EAE), an animal model of multiple sclerosis (MS). To investigate the role of HO -1 in EAE, a putative inhibitor [tin-pro toporphyrin IX (Sn-PP IX)] of HO -1 was administered to SJL mice during active disease. Sn-PP IX (200 mmol/kg) attenuated clinical scores, weight loss, and some signs of patho logy in comparison to vehicle treatment. G lutathione levels were greater in treated EAE mice than in those receiving vehicle, indicating lower oxidative stress in the former group. These data suggest that inhibition of HO -1 attenuated disease and suppressed free radical production. In the SJL model of EAE, extravasated blood is present in the C NS, and iron released by HO -1 from this heme source may not be adequately sequestered by ferritin, allowing for iron-mediated tissue damage. Thus, HO -1 may act to amplify the disease process in this model.Keywords
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