Divergent Changes of Serum 3,5,3‘‐Triiodothyronine and 3,3’,5‘‐Triiodothyronine in Patients with Acute Myocardial Infarction

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Abstract
The serum levels of thyroxine (T4), 3,5,3''-triiodothyronine (T3), 3,3'',5''-triiodothyronine (reverse T3, rT3), thyroxine-binding globulin and thyroid-stimulating hormone were monitored in 13 patients with acute myocardial infarction. The major changes recorded were a transient decrease in T3 and a transient increase in rT3. They reached a nadir and a peak, respectively, within 3 days. A conceivable explanation for these alterations is that the monodeiodination of T4 is diverted from the activating pathway (T4 to T3) to the inactivating pathway (T4 to rT3).