CLASSIFICATION OF CARDIOACTIVE DRUGS IN VIVO BY USING PROGRAMMED ELECTRICAL STIMULATION IN COMBINATION wITH MONOPHASIC ACTION POTENTIAL RECORDINGS AT DIFFERENT PACING RATES
- 12 January 1981
- journal article
- research article
- Published by Wiley in Acta Medica Scandinavica
- Vol. 209 (S645) , 37-46
- https://doi.org/10.1111/j.0954-6820.1981.tb02599.x
Abstract
The effect of antiarrhythmic drugs on myocardial refractoriness may be due to changes in Vmax [maximum rate of rise] of phase 0 and/or the phase of repolarization of the action potential. By using programmed electrical stimulation combined with monophasic action potential recordings at different pacing rates in the intact dog heart, it was possible to classify, and to a certain extent, elucidate, the mode of action of various cardioactive drugs in vivo.Keywords
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