A Comparison of Short-Term, Intensive Prednisone and Acetylsalicylic Acid Therapy in the Treatment of Acute Rheumatic Fever

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Abstract
AT the present time there is no general agreement on whether or not steroid therapy prevents residual rheumatic heart disease. During the past decade Wilson and her co-workers1 2 3 4 5 have presented a series of papers stating that very large doses of prednisone given for an average of seven days in the majority of cases terminated the activity of the rheumatic process and prevented residual rheumatic heart disease. None of these reports, however, included observations on a concurrent group treated with acetylsalicylic acid. In a previous study by the Combined Rheumatic Fever Study Group, the effect of moderate doses of prednisone continued . . .