Enantioselective trimethylsilylcyanation of some aldehydes catalysed by titanium alkoxide–chiral dialkyl tartrate complexes
- 1 January 1992
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 22,p. 3135-3140
- https://doi.org/10.1039/p19920003135
Abstract
Highly enantioselective trimethylsilylcyanation of various aldehydes with trimethylsilyl cyanide has been achieved with a modified Sharpless catalyst, consisting of titanium tetraisopropoxide [Ti(OPri)4] and chiral diisopropyl tartrate (DIPT). Asymmetric amplification was also observed in the trimethylsilylcyanation of benzaldehyde with a catalyst composed of Ti(OPri)4 and partially resolved DIPT.Keywords
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