In-vitro andin-vivo activities of antimicrobial agents againstAcinetobacter calcoaceticus
- 1 April 1985
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy
- Vol. 15 (4) , 441-448
- https://doi.org/10.1093/jac/15.4.441
Abstract
The virulence of clinical isolates ofAcinetobactercal coaceticus subsp.anitratus was studied in mice, andin-vitro andin-vivo activities of several antimicrobial agents were evaluated Inm-vitro susceptibility testings, tetracyclines, aminoglycosides, and peptide were highly sensitive, and nunocycline and doxycycline were the most active of 21 antibiotics tested against 84 clinical isolates of Acin. calcoaceticus. Virulence tests for mice revealed that some strains exhibited high virulence with LD50 values between 103 and 10* viable cells/mouse. Against lethal and urinary tract infections produced by Acin. calcoaceticus Ac-54 strain in mice, minocycline, doxycycline, gentamicin, and dibekacin, which were highly active in vitro, were effective.Keywords
This publication has 2 references indexed in Scilit:
- Meningitis Due toMima PolymorphaAmerican Journal of Clinical Pathology, 1966
- INFECTIONS CAUSED BY MIMEAE WITH SPECIAL REFERENCE TO MIMA POLYMORPHA - A REVIEW1966