Potential neuroleptic agents. 2,6-Dialkoxybenzamide derivatives with potent dopamine receptor blocking activities
- 1 November 1982
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 25 (11) , 1280-1286
- https://doi.org/10.1021/jm00353a003
Abstract
A series of some novel N-(1-ethyl-2-pyrrolidinylmethyl)benzamides was synthesized and tested for dopamine [DA] receptor blockade in vivo by the ability to block the apomorphine syndrome in the rat. Several compounds were considerably more potent than sulpiride as DA receptor blockers and displayed low liability to induce extrapyramidal side effects (catalepsy) in the rat. The blockade of DA receptor activity in vivo was mainly confined to the levorotatory isomers having the S absolute configuration. The structure-activity relationships are discussed.This publication has 6 references indexed in Scilit:
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