Mutants of avian myelocytomatosis virus with smaller gag gene-related proteins have an altered transforming ability
- 1 November 1980
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 288 (5787) , 170-172
- https://doi.org/10.1038/288170a0
Abstract
Avian myelocytomatosis virus strain MC29-transformed cells contain a gag-related protein of a 110,000 MW (p110), a fusion product comprised of gag gene-derived sequences, and sequences which are presumed to be coded by the adjacent mac gene. Three mutants of MC29 that synthesize smaller gag gene-related proteins had an altered ability to transform [chicken] bone marrow cells, but not fibroblasts. This demonstrates for the 1st time a direct involvement of the p110 protein of MC29 in transformation.Keywords
This publication has 10 references indexed in Scilit:
- Comparative tryptic peptide mapping studies suggest a role in cell transformation for the gag-related protein of avian erythroblastosis virus and avian myelocytomatosis virus strains CMII and MC29.Proceedings of the National Academy of Sciences, 1980
- Three New Types of Viral Oncogenes in Defective Avian Leukemia Viruses. II. Biological, Genetic, and Immunochemical EvidenceCold Spring Harbor Symposia on Quantitative Biology, 1980
- Three New Types of Viral Oncogenes in Defective Avian Leukemia Viruses. I. Specific Nucleotide Sequences of Cellular Origin Correlate with Specific TransformationPublished by Cold Spring Harbor Laboratory ,1980
- Mutant avian erythroblastosis virus with restricted target cell specificityNature, 1979
- Three new types of viral oncogene of cellular origin specific for haematopoietic cell transformationNature, 1979
- Specific RNA sequences and gene products of MC29 avian acute leukemia virusProceedings of the National Academy of Sciences, 1978
- Defectiveness of avian myelocytomatosis virus MC29: Isolation of long-term nonproducer cultures and analysis of virus-specific polypeptide synthesisVirology, 1977
- Two types of target cells for transformation with avian myelocytomatosis virusVirology, 1973