Mechanisms of 5′-Inosinic Acid Accumulation by. Permeability Mutants ofBrevibacterium ammoniagenes. II. Sensitivities of a Series of Mutants to Various Drugs

Publisher Website
Google Scholar
Abstract
A series of mutants of Brevibacterium ammoniagenes selected for increased productivity of 5′-inosinic acid (5′-IMP) after successive mutational works were analyzed for the level of sensitivity to a variety of drugs. It was found that the series of mutants exhibited variations in sensitivity to various drugs such as antibiotics, detergents, dyes and lysozyme. The most notable alterations were found in a Mn-insensitive mutant, KY13171, and a guanine auxotrophic mutant, KY13184, compared to each parent mutant. Furthermore, it was found that increased 5′-IMP productivity was always accompanied by increased sensitivity to deoxycholate and lysozyme, and that both the increased level of 5′-IMP production and increased degrees of sensitivity to these two drugs in all steps of mutation were not so drastic, but progressive.