Malignant Lymphoma of the Small Bowel Associated with Diffuse Nodular Lymphoid Hyperplasia

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Abstract
BENIGN intestinal nodular lymphoid hyperplasia (NLH) is a well-known entity, involving the entire small bowel or the colon (or both) of patients with primary immunodeficiency syndromes1 2 3 or the terminal ileum or colon (or both) of children without immunodeficiency.4 In immunodeficient subjects, the association of NLH with non-Hodgkin's intestinal lymphoma seems extremely rare5 6 7 and was suggested to be fortuitous,5 even though malignant conditions (e.g., gastric and colonic adenocarcinoma and extra-digestive lymphoid neoplasms) are frequent in this patient population.1 More recently, in developed Western countries, symptomatic diffuse NLH of the small bowel has been reported in a few adults without detectable immunodeficiency. . . .