Nephrotoxic Potential of Bence Jones Proteins
Open Access
- 27 June 1991
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 324 (26) , 1845-1851
- https://doi.org/10.1056/nejm199106273242603
Abstract
The renal manifestations of diseases associated with the production of monoclonal light chains—myeloma (cast) nephropathy, light-chain deposition disease, and amyloidosis AL—result from the deposition of certain Bence Jones proteins as tubular casts, basement-membrane precipitates, or fibrils, respectively. For unknown reasons, the severity of the renal manifestations of these diseases varies greatly from patient to patient. We employed an experimental in vivo model to determine the pathologic importance of various Bence Jones proteins.Keywords
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