Effect of Pharmacologic Conditioning on Sulfadiazine Toxicity and Concentrations in Plasma

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Abstract
In female rats, pretreatment with pregnenolone-16α-carbonitrile (PCN), spironolactone or CS-11 reduced the toxicity of sulfadiazine; the first two steroids also decreased its concentrations in plasma. Prednisolone acetate, triamcinolone, estradiol and thyroxine increased mortality. The levels of sulfadiazine in plasma were elevated by triamcinolone and not significantly altered by ACTH. Phenobarbital failed to protect or sensitize. Apparently, the steroids (and ACTH) affect resistance through different biochemical mechanisms.

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