REDUCTION OF ANTIGEN‐INDUCED CONTRACTION OF SENSITIZED HUMAN BRONCHUS in vitro BY INDOMETHACIN
Open Access
- 1 August 1975
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 54 (4) , 495-497
- https://doi.org/10.1111/j.1476-5381.1975.tb07596.x
Abstract
Contraction of passively sensitized human bronchus induced by antigen challenge in vitro, was reduced by the prostaglandin F2α synthetase inhibitor, indomethacin. Prostaglandin F2α was released during challenge and this release was inhibited by indomethacin. There was a significant correlation between prostaglandin F2α release and antigen challenge‐induced contraction, suggesting that this substance may contribute to the bronchoconstrictor response of sensitized human bronchus to antigen.Keywords
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