Does Reversal of Ischemia on Diffusion‐Weighted Imaging Reflect Higher Apparent Diffusion Coefficient Values?
- 1 July 2001
- journal article
- case report
- Published by Wiley in Journal of Neuroimaging
- Vol. 11 (3) , 313-316
- https://doi.org/10.1111/j.1552-6569.2001.tb00053.x
Abstract
This study investigated whether ischemia on diffusion-weighted imaging (DWI) that reverses has higher apparent diffusion coefficients (ADCs). A patient treated with thrombolytics was evaluated with serial magnetic resonance imaging studies before treatment, at 3 and 14 days and at 4 weeks. A 100.01-cm3 left frontoparietal stroke on baseline DWI was only 18.11 cm3 (18%) on 4-week fluid attenuated inversion recovery. The mean ADC was 7.43 x 10(-3) mm2/s in the 6 regions that reversed and 7.31 x 10(-3) mm2/s in the 6 regions that persisted (P < .036). With thrombolytic treatment, large ischemic lesions on DWI may reverse, and these areas display higher mean ADCs.Keywords
This publication has 13 references indexed in Scilit:
- Evaluation of early reperfusion and IV tPA therapy using diffusion- and perfusion-weighted MRINeurology, 1999
- MRI abnormalities associated with partial status epilepticusNeurology, 1999
- Clinical utility of diffusion‐weighted magnetic resonance imaging in the assessment of ischemic strokeAnnals of Neurology, 1997
- Enlargement of human cerebral ischemic lesion volumes measured by diffusion‐weighted magnetic resonance imagingAnnals of Neurology, 1997
- Hyperacute stroke: evaluation with combined multisection diffusion-weighted and hemodynamically weighted echo-planar MR imaging.Radiology, 1996
- Clinical Outcome in Ischemic Stroke Predicted by Early Diffusion-Weighted and Perfusion Magnetic Resonance Imaging: A Preliminary AnalysisJournal of Cerebral Blood Flow & Metabolism, 1996
- Combined Perfusion and Diffusion-Weighted Magnetic Resonance Imaging in a Rat Model of Reversible Middle Cerebral Artery OcclusionStroke, 1995
- Acute human stroke studied by whole brain echo planar diffusion‐weighted magnetic resonance imagingAnnals of Neurology, 1995
- Magnetic resonance imaging assessment of evolving focal cerebral ischemia. Comparison with histopathology in rats.Stroke, 1994
- High-Speed MR Imaging of Ischemic Brain Injury following Stenosis of the Middle Cerebral ArteryJournal of Cerebral Blood Flow & Metabolism, 1993