PARTICIPATION OF RENAL, BUT NOT OF SUBMAXILLARY RENIN IN THE HOMEOSTASIS OF THE BLOOD PRESSURE AFTER EXPERIMENTALLY INDUCED HYPOTENSION IN MICE

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Abstract
Hypotension elicited a marked increase in plasma renin concentration in conscious normal mice but no increase was provoked in previously nephrectomized mice in spite of the high renin content of their submaxillary glands. The role of the increased release of renal renin for the homeostasis of the blood pressure was shown by the decrease in pressure which followed blockade of the renin system. Contrary to Saralasin which did not change the blood pressure in nephrectomized mice, injections of SQ 20,881 [a sympathetic nonapetide] did in some mice result in a decrease in blood pressure which was probably caused by its ability to inhibit bradykininases. Both Saralasin and SQ 20,881 elicited marked increases in plasma renin in normal but not in nephrectomized mice, showing that while renal release is controlled by the plasma angiotensin II concentration this does not apply to submaxillary renin release.