Infection of specific-pathogen free lambs with a herpesvirus isolated from pulmonary adenomatosis

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Abstract
Summary In two experiments, 18 specific-pathogen free (SPF) lambs were inoculated by several routes with the Scottish strain of caprine herpesvirus 1 (CHV1). Seventeen of the lambs developed interstitial changes in the lungs ranging from focal cellular infiltration to a widespread proliferative pneumonia. Five weeks after the initial inoculation 3 lambs were given a course of corticosteroid by intravenous injection. Subsequently virus was reisolated from all 3 lambs. Virus was also recovered from one of these lambs on one occasion prior to steroid treatment. It has therefore been established that CHV1 can cause pneumonia and can be reisolated from infected sheep for at least 6 weeks after infection. It is suggested that CHV1 might cause a latent infection in sheep which is reactivated following the development of pulmonary adenomatosis.

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