Thirty-eight patients with advanced, recurrent, or metastatic pelvic sarcomas were treated with combined irradiation and chemotherapy. Fourteen of these patients are presently alive and well without evidence of disease for 10 to 79 months following completion of their therapy. The complications of this combined therapy have been severe, but few, if any, of these patients could have been expected to live with conventional therapy with either chemotherapy alone or irradiation therapy alone. A decrease in the dosage of vincristine would have prevented several of the deaths. A change in order of administering whole pelvis and whole abdomen irradiation combined with chemotherapy possibly will prevent some of the bowel injuries associated with this treatment.