Relationship Between Insulin Resistance, Soluble Adhesion Molecules, and Mononuclear Cell Binding in Healthy Volunteers

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Abstract
The relationship between insulin resistance, soluble adhesion mol- ecules E-selectin (sE-selectin), intracellular adhesion molecule-1 (sICAM-1), and vascular adhesion molecule-1 (sVCAM-1), mononu- clear cell binding to cultured endothelium, and lipoprotein concen- trations were evaluated in 28 healthy, nondiabetic, and normotensive individuals. The mean (6SEM) lipid and lipoprotein concentrations were within the normal rage: cholesterol (199 6 18 mg/dL); triglyc- eride (128 6 12 mg/dL); low-density cholesterol (127 6 8 mg/dL; and high-density cholesterol (47 6 3 mg/dL). The results indicated that degree of insulin resistance was significantly correlated with concen- trations of sE-selectin (r 5 0.54, P , 0.005), sICAM-1 (r 5 0.67, P , 0.001), and sVCAM-1 (r 5 0.41, P , 0.05). Furthermore, the rela- tionship between insulin resistance and both sE-selectin and sI- CAM-1 remained statistically significant when adjusted for differ- ences in age, gender, body mass index, and all measures of lipoprotein concentrations. Finally, mononuclear cell binding correlated signifi- cantly with concentrations of sE-selectin (r 5 0.54, P , 0.005) and sICAM-1 (r 5 0.47, P , 0.01). These findings raise the possibility that previously described relationships between soluble adhesion mole- cules in patients with hypertension, type 2 diabetes, and dyslipidemia may be due to the presence of insulin resistance in these clinical syndromes and suggests that insulin resistance may predispose in- dividuals to coronary heart disease by activation of cellular adhesion molecules.(J Clin Metab Endocrinol 84: 3485-3489, 1999)

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