The Production of High Titre Rh (D) Antibody in Male Volunteers

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Abstract
13 male volunteers, all group A Rh‐negative, were immunised with fresh A Rh‐positive washed red cells. All 13 produced anti‐D. The antibody produced was to be used in the prevention of Rh haemolytic disease. In 8 of the 13 donors, the antibody was of a sufficiently high albumin titre (128 or more) to be used as intended. By plasmapheresis, these eight volunteers have so far donated 149 units of plasma. The first volunteers started the course of injections in March 1970. The first antibody of sufficiently high titre to make plasmapheresis worthwhile was obtained in February 1971. The shortest interval from first injection to first donation was 39 weeks.

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