TNF- and Cancer Therapy-Induced Apoptosis: Potentiation by Inhibition of NF-κB

1 November 1996

journal article
other
Published by American Association for the Advancement of Science (AAAS) in Science

Vol. 274 (5288) , 784-787
https://doi.org/10.1126/science.274.5288.784

Abstract

Many cells are resistant to stimuli that can induce apoptosis, but the mechanisms involved are not fully understood. The activation of the transcription factor nuclear factor-kappa B (NF-κB) by tumor necrosis factor (TNF), ionizing radiation, or daunorubicin (a cancer chemotherapeutic compound), was found to protect from cell killing. Inhibition of NF-κB nuclear translocation enhanced apoptotic killing by these reagents but not by apoptotic stimuli that do not activate NF-κB. These results provide a mechanism of cellular resistance to killing by some apoptotic reagents, offer insight into a new role for NF-κB, and have potential for improvement of the efficacy of cancer therapies.

Keywords

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