Clinical Pharmacokinetics

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Abstract
(Second of Two Parts*)Modes of AdministrationAlthough drugs such as aminophylline, diazoxide, furosemide and lidocaine are actually administered by rapid intravenous injection, other modes of drug administration are obviously more common. All present special pharmacokinetic challenges and opportunities.Continuous Intravenous InfusionMany clinically important drugs are often given by intravenous infusion. They include aminophylline, isoproterenol, lidocaine, nitroprusside, norepinephrine, trimethaphan, and sometimes heparin. The pharmacokinetics of a constant-rate infusion12 , 13 can be described by modification of Equation 1 to include the rate of drug infusion (Q) into the central compartment: Solving the two simultaneous differential equations (Equations 2 and 13) . . .

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