Variation in serum glucose, serum free fatty acids, and liver glycogen concentrations and development of gastric erosions in mice subjected to stress.

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Abstract
Mice were subjected to stress consisting of restraint and water immersion and the variation in serum glucose, serum free fatty acids (FFA), and liver glycogen concentrations and the development of gastric erosions were determined at given intervals for a period of 18 hr. In control mice which were deprived of food and drinking water, no significant variation was observed in serum glucose and FFA levels throughout the experimental period. In contrast, their liver glycogen content was virtually exhausted 9-12 hr after fasting and then began to accumulate, resuming its 6-hr value 18-24 hr after fasting. In stressed mice, serum glucose levels decreased after 1-3 hr of stress and increased thereafter, showing a significant elevation in the levels compared with its 3-hr value 18 hr after stress. On the contrary, FFA levels increased for the initial 1-3-hr period, declined 12 hr after stress, and showed a significant decrease compared with the corresponding value in the control group 18 hr after stress. Liver glycogen was practically exhausted for the first 12-hr period after stress. Thereafter, its levels increased but was still lower than those in the control group 18 hr after stress. Gastric erosions were generated after 1 hr of stress and developed with the progress of time, reaching the highest severity of erosions at the end of stress.

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