Generalized oedema of newborn associated with the administration of dipyrone

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Abstract
In fourteen infants, aged 9–60 days, with generalized oedema seen during a one year period the common denominator was the administration of dipyrone one to two days prior to the development of oedema. None of the other causes of oedema in early life could be incriminated in any of these babies. Pediatricians should be aware of this iatrogenic cause whenever they encounter a young infant with generalized oedema. Oedema disappeared in all the cases following discontinuation of dipyrone but anuria lasted for more than four days in one case. This study re-emphasizes the need to withold this potentially dangerous drug, especially during the neonatal period.