Patterns of infant mortality caused by major congenital anomalies

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Abstract
Background We assessed the impact of recent advances in perinatal care on infant mortality due to congenital anomaly. Methods Analysis of trends in congenital anomaly-attributed infant mortality, using the 1981–1995 Statistics Canada's birth and death records, with a total of 2,878,826 live births, 21,883 infant deaths, and 6,908 infant deaths due to congenital anomalies. Results Infant mortality due to major congenital anomaly decreased from 3.11 per 1,000 live births in 1981 to 1.89 per 1,000 live births in 1995. Cause-specific infant mortality rates for anencephaly, spina bifida, other central nervous system anomalies, cardiovascular system anomalies, respiratory system anomalies, digestive system anomalies, certain musculoskeleton anomalies, urinary system anomalies, chromosomal anomalies, and multiple congenital anomalies were 0.20, 0.23, 0.27, 1.04, 0.24, 0.08, 0.22, 0.16, 0.22, and 0.13 per 1,000 live births, respectively, in 1981–1983, whereas corresponding rates were 0.07, 0.07, 0.18, 0.73, 0.25, 0.03, 0.12, 0.12, 0.26, and 0.06 per 1,000 live births, respectively, in 1993–1995. Conclusions Recent Canadian data show that infant deaths caused by major congenital anomalies have decreased significantly, but reductions varied substantially according to specific forms of anomalies. Teratology 61:342–346, 2000.