SERUM CONCENTRATIONS OF 25-HYDROXYVITAMIN-D AND 24,25-DIHYDROXYVITAMIN-D IN PATIENTS WITH VARIOUS TYPES OF RENAL-DISEASE

  • 1 January 1980
    • journal article
    • research article
    • Vol. 14  (6) , 274-279
Abstract
Serum concentrations of 25-hydroxyvitamin D (25 OHD) and 24,25-dihydroxyvitamin D (24,25(OH)2D) in patients with various types of renal disease were measured by a competitive protein binding assay. There was a significant (P < 0.001) inverse correlation between serum levels of either 25 OHD or 24,25(OH)2D and the degree of proteinuria in patients with chronic glomerulonephritis or idiopathic nephrotic syndrome. The ratio of 24,25(OH)2D to 25 OHD was relatively low in patients with creatinine clearances (CCr) less than 30 ml/min per 1.48 m2, while the ratio was higher in those with clearances greater than 85 ml/min per 1.48 m2. There was a linear correlation (r = 0.783, P < 0.001) between the ratio and the CCr in patients whose CCr ranged from 30 to 85 ml/min per 1.48 m2. The 24,25(OH)2D/25 OHD ratio also appeared to be correlated significantly (P < 0.001) with the PSP[phenolsulfon-phthalein]-test. The serum levels of 25 OHD and 24,25(OH)2D were lowered in nephrotic patients during treatment with prednisolone. The serum levels of 24,25(OH)2D were increased by 1.alpha.-hydroxyvitamin D3 treatment in patients with chronic renal failure.