Ultrastructural localization of serotonin in the intrapulmonary neuroepithelial bodies of neonatal rabbits by use of immunoelectron microscopy
- 1 March 1986
- journal article
- Published by Springer Nature in Cell and tissue research
- Vol. 243 (3) , 455-459
- https://doi.org/10.1007/bf00218051
Abstract
The ultrastructural localization of serotonin in neuroepithelial bodies (NEB) of neonatal rabbits was examined by use of the recently developed immunogold-staining method. In the granulated epithelial cells of NEB serotoninimmunoreactive material could be demonstrated only in dense-cored vesicles (DCV) of the first type. No immunoreactivity was observed in DCV of the second type. The present findings support the previously made suggestion that the corpuscular NEB cells contain two distinctive DCV types which react differently with the immunogold-staining procedure for identifying serotonin. NEB, known as intrapulmonary sources of serotonin (and peptide substances), may play a prominent role in lung physiology.Keywords
This publication has 23 references indexed in Scilit:
- Innervation of rabbit intrapulmonary neuroepithelial bodiesJournal of the Neurological Sciences, 1985
- The intrapulmonary neuroepithelial bodies after vagotomy: demonstration of their sensory neuroreceptor-like innervationCellular and Molecular Life Sciences, 1983
- Morphological and Cytochemical Characterization of Neuroepithelial Bodies in Fetal Rabbit Lung I. Studies of Isolated Neuroepithelial BodiesExperimental Lung Research, 1982
- Bombesin, calcitonin and leu-enkephalin immunoreactivity in endocrine cells of human lungCellular and Molecular Life Sciences, 1981
- Localization of serotonin in the central nervous system by immunohistochemistry: Description of a specific and sensitive technique and some applicationsNeuroscience, 1978
- Bombesin-like immunoreactivity in the lungNature, 1978
- Microspectrography of formaldehyde and fluorescamine-induced fluorescence in rabbit pulmonary neuroepithelial bodies: Demonstration of a new, probably polypeptide intracytoplasmic substanceCellular and Molecular Life Sciences, 1977
- Ultrastructure of nerves and associated cells in bronchiolar epithelium of the mouse lungJournal of Ultrastructure Research, 1973
- Neuro‐epithelial bodies (neuroreceptor or Secretory Organs?) in Human Infant Bronchial and Bronchiolar EpitheliumThe Anatomical Record, 1972
- CYTOCHEMISTRY OF 5-HYDROXYTRYPTAMINE AT THE ELECTRON MICROSCOPE LEVEL I. STUDY OF THE SPECIFICITY OF THE REACTION IN ISOLATED BLOOD PLATELETSJournal of Histochemistry & Cytochemistry, 1968